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Coronary Artery Disease and Metabolic Syndrome (Syndrome X)


Metabolic Syndrome and Coronary Artery DiseaseMetabolic Syndrome, also known as Syndrome X, greatly increases the likelihood of developing coronary artery disease (CAD). This latter disorder occurs when the arteries supplying blood to the heart muscle become hardened and narrowed.

The deterioration is caused by a build-up of plaque on the inner walls or lining of the arteries. Plaque, which consists of a substance containing cholesterol, calcium, clotting proteins and other compounds, reduces blood flow to the heart and oxygen supply to the heart muscle.

This process is divided into three distinct variants and can occur due to the build-up of fat deposits (plaque) on the inner walls of arteries (atherosclerosis), calcification of the wall of the arteries (Monckeberg's medial calcific sclerosis), or thickening of the muscular wall of small arteries and arterioles (arteriolosclerosis).

Coronary artery disease is the most common type of heart disease and the leading cause of death in the United States in both men and women.

When blood flow and oxygen supply to the heart are reduced or cut off, you can develop:

Angina – a chest pain or discomfort that occurs when your heart is not getting enough blood.

Metabolic Syndrome and Coronary Artery DiseaseHeart attack – this happens when a blood clot suddenly cuts off most or all blood supply to part of the heart. Cells in the heart muscle that do not receive enough oxygen-carrying blood begin to die. This can cause permanent damage to the heart muscle.

Over time, coronary artery disease can weaken your heart muscle and contribute to:

Heart Failure – this occurs when the heart is not able to pump blood to the rest of the body effectively. Heart failure does not mean that your heart has stopped or is about to stop working. But it does mean that your heart is failing to pump blood the way that it should.

Arrhythmia – changes in the normal rhythm of the heartbeats, some of which can be quite serious.

An underlying cause of coronary artery disease, Metabolic Syndrome is characterized by a group of risk factors present in one person. They include:

  • Abdominal obesity – excessive fat tissue in and around the abdomen

  • Atherogenic dyslipidemia – blood fat disorders like high triglycerides, low HDL "good" cholesterol and high LDL "bad" cholesterol which foster plaque build up in artery walls

  • Elevated blood pressure

  • Insulin Resistance – an underlying factor in obesity caused by the body's inability to properly use blood sugar and insulin

  • Prothrombotic state – the presence of high fibrinogen or plasminogen activator inhibitor–1 in the blood stream

  • Proinflammatory state – the presence of elevated C-reactive protein in the blood
Metabolic Syndrome sufferers are at increased risk of Cardiovascular Disease as well as coronary artery disease and other disorders related to plaque build up like stroke and peripheral vascular disease, as well as Pre- and Type 2 Diabetes. More than 50 million Americans are estimated to have Metabolic Syndrome.

Obesity caused by the glucose and insulin imbalance called Insulin Resistance is a key risk factor for Metabolic Syndrome. The American Heart Association and the National Heart, Lung, and Blood Institute advise that Metabolic Syndrome sufferers can be identified by having three or more of these components:
  • Elevated waist circumference:
    Men – Equal to or greater than 40 inches (102 cm)
    Women – Equal to or greater than 35 inches (88 cm)

  • Elevated triglycerides:
    Equal to or greater than 150 mg/dL

  • Reduced HDL ("good") cholesterol:
    Men – Less than 40 mg/dL
    Women – Less than 50 mg/dL

  • Elevated blood pressure:
    Equal to or greater than 130/85 mm Hg

  • Elevated fasting glucose:
    At least 110 mg/dL
The primary goal of someone suffering from Metabolic Syndrome is to reduce the risk for coronary artery disease as well as Cardiovascular Disease and Pre-Diabetes. The latter is a reversible condition which is diagnosed when blood sugar levels are higher than normal but not elevated enough for Type 2 Diabetes. If neglected, however, Pre-Diabetes can lead to Type 2 Diabetes, which is irreversible in the vast majoity of cases and may require daily injections of insulin for the rest of a Diabetic's life. Type 2 Diabetes, itself, is a severely increased risk factor for blindness, kidney disease and the need for amputation.

Lifestyle changes are crucial to reduce LDL cholesterol, hypertension (high blood pressure) and glucose and insulin levels.

Metabolic Syndrome and Coronary Artery DiseaseThere is no one pill to counter Metabolic Syndrome. We feel a complete system is required to reverse this condition – one that includes nutraceuticals (vitamins, herbs and minerals that are disease specific), a realistic exercise program combined with nutritional guidance, advice on combating carbohydrate addiction and a support network that will help you change unhealthy lifestyle choices. Together, these factors can result in:
  • Weight loss to achieve a desirable objective (a BMI, or Body Mass Index, of less than 25 kg/m2)

  • Increased physical activity, with a goal of at least 30 minutes of moderate-intensity activity on 5 or more days per week

  • Healthy eating habits that include reduced intake of saturated fat, trans fat and cholesterol
Click here to read about the ground-breaking Insulite MetaX System, which is scientifically-designed to reverse Insulin Resistance and its related risk of coronary artery disease. The system includes a formulation called RejuvenX that can improve circulation with antioxidant ingredients like CoQ10 and bilberry extract.

You may be interested in some of our Frequently Asked Questions (FAQs) about Metabolic Syndrome and the Insulite MetaX System.

Click here to read about
Metabolic Syndrome and Hypertension (High Blood Pressure)




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Insulin Resistance Articles
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Teresa Ruth
  Boise, Idaho
"Researchers agree that insulin resistance is central to the metabolic syndrome. When target cells are unresponsive to insulin, the pancreas responds by pouring even more insulin into the bloodstream, leading to high levels of the hormone in the blood, a condition called compensatory hyperinsulinemia. The high level of insulin in the blood forces glucose into cells but also starts the events leading to arterial damage and eventually a heart attack. Under these conditions, a person may not manifest either diabetes or heart disease but could well be on the way to either or both."
A. MAUREEN ROUHI, Chemical and Engineering News. November 22, 2004.Vol. 82, No.47  
"I wanted to let you know how much I appreciate your caring advice and guiding me towards taking control of my health. It's hard to express in words how long I have been trying to find the answers you have so easily provided for me.

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MS
  Stuarts Draft, VA
"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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"A non-pharmacologic treatment for these patients is needed, since drugs prescribed to lower blood pressure have been shown to actually worsen carbohydrate and lipid metabolism in Syndrome X patients, negating the beneficial effects of those drugs."
Duke University Study, results published in the Archives of Internal Medicine, September 2003.
Article by Dr. Sheri Colberg, Phd, FACSM
"I cannot believe the difference the Insulite System has made in how I feel. My appetite has changed tremendously. I do not crave carbs and sugar and my appetite is somewhat diminished."
PR
  Bakersfield, CA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
"To gain the most benefit from modifying multiple metabolic risk factors, the underlying insulin-resistant state must become a target of therapy."
Bogdanovic, Streten and Langlans, Beata, "Metabolic Syndrome: New Opportunities in Diagnostics and Therapeutics", DMD Publications, 2004.  
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