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High Cholesterol and Metabolic Syndrome

Information about Metabolic Syndrome and High CholesterolHigh cholesterol is a key symptom of Metabolic Syndrome, which can damage the cardiovascular system and lead to a heart attack or stroke.

When the body becomes Insulin Resistant, it begins a cycle which leads to the release of more and more insulin to compensate. This condition is called hyperinsulinemia as pancreatic insulin secretion rises to maintain normal levels of glucose in the blood stream. Hyperinsulinemia can then stimulate lipid storage (fat storage throughout the body) and altered lipoprotein (higher levels of cholesterol) which increase the risks of damage to the cardiovascular system. Combating hyperinsulinemia is a crucial factor in heart disease prevention.

The resulting excess of insulin in hyperinsulinemia also encourages the liver to produce more of the blood lipids called triglycerides. This blood fat disorder is called Dyslipidemia, which fosters plaque build-up in artery walls. Dyslipidemia is diagnosed when LDL "bad" cholesterol is high, HDL ("good" cholesterol) is low, triglyceride levels are high or there is a combination of all these factors, which are associated with an increased risk for heart disease.

Additionally, LDL cholesterol particles seen in people who suffer from Insulin Resistance and Metabolic Syndrome (Syndrome X) are smaller and more dense than the particles of people without this condition. This factor has been directly linked to an increased risk of Cardiovascular Disease, heart attacks and stroke, although the exact cause of the relationship is unclear.

Increased levels of the “bad” cholesterol (LDL, or low-density lipoprotein) are one of the underlying symptoms that will trigger a diagnosis of Metabolic Syndrome. Obesity, high blood lipids, poor diet and physical inactivity are known to have an effect on the development of high levels of cholesterol.

high cholesterolA woman with PCOS (Polycystic Ovarian Syndrome) also often displays signs of Metabolic Syndrome. These may include high blood pressure, Type 2 Diabetes and excessive abdominal fat, all high risk factors for developing Cardiovascular Disease, heart attacks and stroke. Scientists and health care professionals have been warning in recent years of the dangers of "high cholesterol", which is actually a reference to LDL, as opposed to the "good" cholesterol, or HDL (high-density lipoprotein.) In general, the lower a person's LDL, and the higher their HDL, the lower the risk of Cardiovascular Disease.

The National Cholesterol Education Program (NCEP) advises that addressing high levels of cholesterol is critical. “But the idea that you can use cholesterol-lowering drugs without lifestyle changes is incorrect," said Scott Grundy, M.D., Ph.D. and the American Heart Association's representative to the NCEP.

"Lifestyle changes have enormous benefits beyond lowering LDL cholesterol, such as raising levels of good cholesterol, lowering triglycerides, improving Diabetes and reducing inflammation of the arteries," he said.

Sticking to a low cholesterol diet may not be enough to improve problems with cholesterol. Although there are approved drugs that can help lower cholesterol levels, there are currently no drugs that will completely reverse the symptoms of Insulin Resistance, Metabolic Syndrome or PCOS. Instead, you must rely on a multi-faceted approach to improving these conditions.

What is required is a complete system, including nutraceuticals (vitamins, herbs and minerals that are disease specific), a realistic exercise program combined with nutritional guidance and a support system that will help you change unhealthy lifestyle choices.

Click here to read about the ground-breaking Insulite MetaX System, which can reverse Insulin Resistance-linked weight gain, a key underlying cause of heart-damaging Metabolic Syndrome. The system includes numerous formulations, including OmegaX, which features omega-3 fatty acids to help reduce the risk of a heart attack or stroke by preventing a build-up of high cholesterol and the onset of high blood pressure (hypertension).

You may be interested in some of our Frequently Asked Questions (FAQs) about Metabolic Syndrome and the Insulite MetaX System.

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Insulin Resistance Articles
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Teresa Ruth
  Boise, Idaho
"Researchers agree that insulin resistance is central to the metabolic syndrome. When target cells are unresponsive to insulin, the pancreas responds by pouring even more insulin into the bloodstream, leading to high levels of the hormone in the blood, a condition called compensatory hyperinsulinemia. The high level of insulin in the blood forces glucose into cells but also starts the events leading to arterial damage and eventually a heart attack. Under these conditions, a person may not manifest either diabetes or heart disease but could well be on the way to either or both."
A. MAUREEN ROUHI, Chemical and Engineering News. November 22, 2004.Vol. 82, No.47  
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  Stuarts Draft, VA
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Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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  Perth, Australia
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"A non-pharmacologic treatment for these patients is needed, since drugs prescribed to lower blood pressure have been shown to actually worsen carbohydrate and lipid metabolism in Syndrome X patients, negating the beneficial effects of those drugs."
Duke University Study, results published in the Archives of Internal Medicine, September 2003.
Article by Dr. Sheri Colberg, Phd, FACSM
"I cannot believe the difference the Insulite System has made in how I feel. My appetite has changed tremendously. I do not crave carbs and sugar and my appetite is somewhat diminished."
  Bakersfield, CA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
"To gain the most benefit from modifying multiple metabolic risk factors, the underlying insulin-resistant state must become a target of therapy."
Bogdanovic, Streten and Langlans, Beata, "Metabolic Syndrome: New Opportunities in Diagnostics and Therapeutics", DMD Publications, 2004.  
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