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Metabolic Syndrome (Syndrome X) and Mental Disorders


Information about Metabolic Syndrome and Mental DisordersMen experiencing heart disease symptoms caused by Insulin Resistance-related Metabolic Syndrome and aged around 50 are more likely to suffer from vascular dementia in their late 70s, according to a report presented to the American Academy of Neurology (1).

Additionally, some studies have examined the relationship between Metabolic Syndrome and psychological risk factors such as depression, anxiety, tension, current perceived stress and anger. Researchers concluded that there was a reciprocal association between anger and Metabolic Syndrome (2). In other words, each side of the equation had an effect on the other – those with Metabolic Syndrome were more likely to experience depression, anxiety, tension etc. and those who were depressed, anxious, stressed, etc. were more likely to develop Metabolic Syndrome.

The exact interaction of these conditions is unclear and it’s still part of a complex neurobiological jigsaw puzzle that scientists continue to study. Early data suggests, however, that Alzheimer's patients showed improved memory after an infusion of insulin, which speaks to the role of glucose metabolism in the physiology of dementia.

Women with Type 2 Diabetes, who have twice the risk of developing depression, showed marked improvement in depressive instances when they received education and treatment for Insulin and Metabolic Syndrome (3).

Click here to read about the ground-breaking Insulite MetaX System, which is scientifically-designed reverse Metabolic Syndrome — a condition often linked to mental disorders. The system includes numerous formulations, including InsulX, which, among other ingredients, includes chromium to balance glucose and insulin levels in the blood stream to aid weight loss, reduce hypertension (high blood pressure) and prevent damage to blood vessels, which can increase the risk of mental disorders.

You may be interested in some of our Frequently Asked Questions (FAQs) about Metabolic Syndrome and the Insulite MetaX System.

(1) High blood pressure, cholesterol and weight increase dementia risk - American Academy of Neurology 52nd Meeting, 2000

(2) The relationship between psychological risk attributes and the metabolic syndrome in healthy women: antecedent or consequence? - Raikkonen K, Matthews KA, Kuller LH. Department of Psychology, University of Helsinki, Helsinki, Finland.CNS Drugs, 2003, 17 (1):27-45

(3) The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment.  - Watson GS, Craft S., Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.


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Insulin Resistance Articles
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"Researchers agree that insulin resistance is central to the metabolic syndrome. When target cells are unresponsive to insulin, the pancreas responds by pouring even more insulin into the bloodstream, leading to high levels of the hormone in the blood, a condition called compensatory hyperinsulinemia. The high level of insulin in the blood forces glucose into cells but also starts the events leading to arterial damage and eventually a heart attack. Under these conditions, a person may not manifest either diabetes or heart disease but could well be on the way to either or both."
A. MAUREEN ROUHI, Chemical and Engineering News. November 22, 2004.Vol. 82, No.47  
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Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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"A non-pharmacologic treatment for these patients is needed, since drugs prescribed to lower blood pressure have been shown to actually worsen carbohydrate and lipid metabolism in Syndrome X patients, negating the beneficial effects of those drugs."
Duke University Study, results published in the Archives of Internal Medicine, September 2003.
Article by Dr. Sheri Colberg, Phd, FACSM
"I cannot believe the difference the Insulite System has made in how I feel. My appetite has changed tremendously. I do not crave carbs and sugar and my appetite is somewhat diminished."
PR
  Bakersfield, CA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
"To gain the most benefit from modifying multiple metabolic risk factors, the underlying insulin-resistant state must become a target of therapy."
Bogdanovic, Streten and Langlans, Beata, "Metabolic Syndrome: New Opportunities in Diagnostics and Therapeutics", DMD Publications, 2004.  
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