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Metabolic Syndrome (Syndrome X) and Pre- and Type 2 Diabetes


Metabolic Syndrome and DiabetesA root cause of Metabolic Syndrome is Insulin Resistance. The latter condition increases the risk of developing Pre-Diabetes and Type 2 Diabetes, which may result in a heart attack or stroke.

People with often Insulin Resistance-linked blood glucose levels that are higher than normal but not yet in the Type 2 Diabetes range have Pre-Diabetes. Doctors sometimes call this condition impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), depending on the blood test used to diagnose it.

The good news is that Pre-Diabetes doesn’t have to lead to Type 2 Diabetes because it can be reversed. But if it is neglected, this disorder may become Type 2 Diabetes, which must be managed for one's lifetime in the vast majority of cases and often requires daily insulin. Type 2 Diabetes, itself, is a severely increased risk factor for blindness, kidney disease and the need for amputation.


So it is critical that you understand the interaction of Insulin Resistance and the various forms of Diabetes in order to learn about heart disease prevention and avoid the onset of other serious health complications.

The human body processes food into glucose, which then passes through the cell wall to be turned into energy via insulin, a hormone produced in the pancreas. Pre-and Type 2 Diabetes are disorders of that metabolism and a malfunction of the process. People with one form or another of Diabetes either cannot use the insulin that is produced or the pancreas produces little or no insulin. As the pancreas struggles to keep up with the body’s need for more insulin, excessive levels of glucose and insulin build up in the blood stream, often leading directly to Pre- and Type 2 Diabetes.

Metabolic Syndrome, also known as Syndrome X, has several tell-tale symptoms: excessive abdominal fat, high LDL "bad" blood cholesterol and low HDL "good" cholesterol, high levels of blood fats called triglycerides and high blood pressure - all implicated in the development of Pre- and Type 2 Diabetes. Metabolic Syndrome, also called Syndrome X, is a disorder that substantially increases your chances of developing Cardiovascular Disease (CVD).

Insulin Resistance and Diabetes are Not the Same

It's important to understand the distinction between Insulin Resistance and the various forms of Diabetes. Insulin Resistance occurs when the body produces enough insulin but its cells are too desensitized to allow the absorption of insulin at a cellular level.
"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.


All of the factors associated with Insulin Resistance and Metabolic Syndrome are interrelated. Obesity and lack of exercise worsen Insulin Resistance, which then has a negative effect on lipid production, increasing VLDL (very low-density lipoprotein), LDL (low-density lipoprotein — the "bad" cholesterol) and triglyceride levels in the blood stream and decreasing HDL (high-density lipoprotein — the "good" cholesterol).

These conditions are increased risk factors for Type 2 Diabetes which is one of the top fatal disorders in the United States. In 2000, it was the sixth leading cause of death and has been associated with long term complications affecting almost every part of the body, leading to blindness, heart and blood vessel disease, stroke, kidney failure, amputations and nerve damage.

Obesity, especially abdominal obesity, is strongly related to Metabolic Syndrome and obese women are particularly susceptible to Pre- and Type 2 Diabetes. A vicious cycle quickly forms because this condition, in turn, puts women at dramatically increased risk of Cardiovascular Disease, as well as the development of many other serious health conditions, including stroke, kidney damage and blindness.

Metabolic Syndrome and DiabetesMany people have been educated about the importance of checking their cholesterol levels, as well as watching for signs of Pre-Diabetes and Type 2 Diabetes, having their blood pressure monitored and exercising regularly. – but there has been little research to tie all of these factors together.

Studies have shown that a single solution will simply not work in trying to address the myriad symptoms of these conditions. While no pharmaceutical has yet been approved by the US Food and Drug Administration (FDA) specifically for Insulin Resistance and Metabolic Syndrome, there are drugs approved for use in the treatment of Type 2 Diabetes.

But a single drug, or even a combination of them, will not eradicate or reverse Insulin Resistance and Metabolic Syndrome. If you wish to return to optimum health, we feel you have to consider a system which combines nutraceuticals (vitamins, herbs and minerals that are disease specific), a realistic exercise program, nutritional guidance, advice on combating carbohydrate addiction and a support system that will help you change unhealthy lifestyle choices to lose weight.

Click here to read about the unique, new Insulite MetaX System, which is scientifically-designed to reverse Insulin Resistance-linked Metabolic Syndrome, which, if left unchecked, can led to Pre- and Type 2 Diabetes. The Insulite System includes numerous formulations like InsulX with ingredients like magnesium, which decreases levels of glucose and insulin to prevent Diabetes.

You may be interested in some of our Frequently Asked Questions (FAQs)
about Metabolic Syndrome and the Insulite MetaX System.

 

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Insulin Resistance Articles
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"Researchers agree that insulin resistance is central to the metabolic syndrome. When target cells are unresponsive to insulin, the pancreas responds by pouring even more insulin into the bloodstream, leading to high levels of the hormone in the blood, a condition called compensatory hyperinsulinemia. The high level of insulin in the blood forces glucose into cells but also starts the events leading to arterial damage and eventually a heart attack. Under these conditions, a person may not manifest either diabetes or heart disease but could well be on the way to either or both."
A. MAUREEN ROUHI, Chemical and Engineering News. November 22, 2004.Vol. 82, No.47  
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  Stuarts Draft, VA
"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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"A non-pharmacologic treatment for these patients is needed, since drugs prescribed to lower blood pressure have been shown to actually worsen carbohydrate and lipid metabolism in Syndrome X patients, negating the beneficial effects of those drugs."
Duke University Study, results published in the Archives of Internal Medicine, September 2003.
Article by Dr. Sheri Colberg, Phd, FACSM
"I cannot believe the difference the Insulite System has made in how I feel. My appetite has changed tremendously. I do not crave carbs and sugar and my appetite is somewhat diminished."
PR
  Bakersfield, CA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
"To gain the most benefit from modifying multiple metabolic risk factors, the underlying insulin-resistant state must become a target of therapy."
Bogdanovic, Streten and Langlans, Beata, "Metabolic Syndrome: New Opportunities in Diagnostics and Therapeutics", DMD Publications, 2004.  
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