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Insulin Resistance, Metabolic Syndrome (Syndrome X) and Serious Conditions


  • Serious ConditionsInsulin Resistance can cause hyperinsulinemia, an excess of insulin in the blood stream and a symptom of Metabolic Syndrome. This latter condition may result in higher levels of LDL "bad" cholesterol that could damage the cardiovascular system and lead to a heart attack or stroke. Reversing Insulin Resistance is an important factor in heart disease prevention.

  • Insulin Resistance heightens the risk of Metabolic Syndrome sufferers becoming Pre-Diabetic which, if neglected, can lead to Type 2 Diabetes - an increased risk factor for Cardiovascular Disease. Insulin Resistance can also cause high blood pressure or hypertension, another risk factor for heart problems.

  • Type 2 Diabetes can only be managed for the rest of a Diabetic's life in the vast majority of cases and may require daily injections of insulin. Just by itself, Type 2 Diabetes is a seriously increased risk factor for blindness, kidney disease and the need for amputation.

  • Researchers have long known that people who are overweight and suffer from Type 2 Diabetes are at greater risk of developing Alzheimer’s Disease and other types of dementia.

  • Men with Metabolic Syndrome run a greater risk of developing prostate cancer.

"... obese children as young as six were experiencing changes in their blood vessels that, when present in adults, are associated with coronary artery disease. The researchers concluded that obesity during childhood, especially when combined with high blood pressure or insulin resistance, should be considered a major risk factor for premature heart disease and cause for treatment. They recommended that children who are obese begin treatment plans that include weight loss and control of any other risk factors for heart disease, such as high blood pressure."
Prevention of Heart Disease Should Begin in Childhood, Diabetes Care, American Diabetes Association
Because there is no single solution for Insulin Resistance and Metabolic Syndrome you might want to consider a multi-faceted approach. We feel that what’s required to address the issues presented by these syndromes is a complete systematic approach, which includes nutraceuticals (vitamins, herbs and minerals that are disease specific), a realistic exercise program combined with nutritional guidance, advice on combating carbohydrate addiction and a support network that will help you change unhealthy lifestyle choices that could lead to weight loss.

Click here to learn about the ground-breaking Insulite MetaX System, which is scientifically-designed to help reverse Metabolic Syndrome, which can lead to other serious disorders like Pre-Diabetes, an increased risk of Alzheimer's Disease and some forms of cancer, as well as heart disease. The system includes numerous formulations like OmegaX, which includes omega 3 fatty acids that can help prevent damage to the cardiovascular system — often the precursor to multiple health threats.

You may be interested in some of our Frequently Asked Questions (FAQs) about Metabolic Syndrome and the Insulite MetaX System.


Click here to read about
Metabolic Syndrome and Diabetes





See below for an article on Syndrome W





Insulin Resistance Links “Syndrome W”
with Syndrome X (Metabolic Syndrome) and Type 2 Diabetes





A New York Medical College doctor has coined the term “Syndrome W” to describe Insulin Resistance-related conditions that can lead to the better-known Cardiovascular Disease disorder called Syndrome X (Metabolic Syndrome) (1). Women who suffer from PCOS (Polycystic Ovarian Syndrome) seem particularly vulnerable to “Syndrome W,” which also may be the precursor to Type II Diabetes.

Endocrinologist Harriet Mogul has screened hundreds of women since the college started its Menopause Health Program in 1994. She quickly began noticing a cluster of symptoms in a certain type of patient who came in to be evaluated for hormone replacement therapy (HRT).

“Among these patients – a narrow range of health-conscious, non-smoking, physically active women approaching menopause – there were many complaints of weight gain, usually around the waist, after years at a constant weight,” said Dr. Mogul.

“When we began seeing these symptoms clustered together with elevated blood pressure and insulin levels, we decided there was a pattern. Women with the syndrome also report a detectable increase in appetite, food cravings and inability to lose weight, despite exercise and attempts to diet.”

Dr. Mogul was sure the women were suffering from Insulin Resistance. She called their weight gain symptoms “Syndrome W” because their condition would lead, alphabetically and medically, to Syndrome X, a cluster of disorders also called Metabolic Syndrome, which include high blood pressure and abnormalities in certain blood fats and blood-clotting factors, resulting in Cardiovascular Disease.

Insulin Resistance occurs when the body has too few insulin receptor sites or “doorways” on the cell walls to allow carbohydrates that have been broken down into blood sugar, or glucose, to pass through and be converted to energy. Insulin acts as “a key in a lock”, allowing blood sugar to enter through the cell wall. It also makes sure there’s never too much sugar in the blood stream by storing excess glucose in the liver and fat cells and shuttling just the right amount needed for energy at any moment to various cells of the body.

Our bodies become Insulin Resistant when our cells no longer “answer the door” to insulin. Obesity is the main factor for triggering the change but heredity also plays a role and even a thin person can become Insulin Resistant.

When glucose is locked out of Insulin Resistant cells, it has nowhere to go and builds up in the blood stream. The pancreas releases yet more insulin to try to compensate and, for a while, that works to force glucose through the cells wall. Someone with Insulin Resistance can maintain normal blood glucose levels but requires insulin levels as much as 40% above normal, which can cause the cluster of significant cardiovascular diseases known as Syndrome X.

In at least a portion of the estimated 60-80 million Americans who are currently Insulin Resistant, the pancreas will eventually lose its fight to maintain balanced levels of glucose and insulin, allowing the glucose level to begin creeping upwards. Untreated, 10% of those who started out simply suffering from Insulin Resistance are likely to develop Type II Diabetes.

It’s only then that people realize they have a problem, which is why Insulin Resistance has been called a “silent killer” because its symptoms have gone largely unrecognized until recently.

A 1999 study by researchers at Washington University in St. Louis reaffirmed what Dr. Mogul had been observing in her female patients; namely that a tendency to accumulate fat at the midriff, creating a so-called apple-shaped body, is a strong marker for Insulin Resistance.

Dr. Mogul is still studying the reason why the Insulin Resistance underlying “Syndrome W” begins in mid-life in her patients. “There seems to be a switch that goes off at 40,” she said. “The genes do change and there are some major metabolic changes at 40.”

Certain groups of women seem particularly vulnerable: “a very high percentage of Asian, Middle Eastern and Hispanic women … also women who have had PCOS (Polycystic Ovarian Syndrome) … and Ashkenazi women.”

Keeping overall weight down is the best way to avoid “Syndrome W”, according to Dr. Mogul. “Watch the calories and watch the carbohydrates. And don’t make the mistake that low-fat means low-calories,” she said.

“Also, oral estrogen is associated with weight gain, so work with your doctor to get the prescription right if you are taking hormones. And exercise!”

(1) Soares, Christine, "Syndrome W", Discovery Health


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Metabolic Syndrome and Pre-Diabetes




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"Researchers agree that insulin resistance is central to the metabolic syndrome. When target cells are unresponsive to insulin, the pancreas responds by pouring even more insulin into the bloodstream, leading to high levels of the hormone in the blood, a condition called compensatory hyperinsulinemia. The high level of insulin in the blood forces glucose into cells but also starts the events leading to arterial damage and eventually a heart attack. Under these conditions, a person may not manifest either diabetes or heart disease but could well be on the way to either or both."
A. MAUREEN ROUHI, Chemical and Engineering News. November 22, 2004.Vol. 82, No.47  
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"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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"A non-pharmacologic treatment for these patients is needed, since drugs prescribed to lower blood pressure have been shown to actually worsen carbohydrate and lipid metabolism in Syndrome X patients, negating the beneficial effects of those drugs."
Duke University Study, results published in the Archives of Internal Medicine, September 2003.
Article by Dr. Sheri Colberg, Phd, FACSM
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PR
  Bakersfield, CA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
"To gain the most benefit from modifying multiple metabolic risk factors, the underlying insulin-resistant state must become a target of therapy."
Bogdanovic, Streten and Langlans, Beata, "Metabolic Syndrome: New Opportunities in Diagnostics and Therapeutics", DMD Publications, 2004.  
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