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Heart Disease and Metabolic Syndrome

Insulin Resistance can be an underlying cause of Metabolic Syndrome, which, if neglected, may lead to coronary artery disease, resulting in a stroke.

People suffering from Metabolic Syndrome, also known as Syndrome X, often have elevated cholesterol levels, high blood pressure, obesity and Insulin Resistance, which all damage the cardiovascular system. Insulin Resistance is an underlying cause of obesity, which, in turn, can be a key factor in the development of Metabolic Syndrome.

Reversing Insulin Resistance can be a crucial factor in heart disease prevention in other ways because it also increases a person's risk of developing Type 2 Diabetes, which sharply increases the likelihood of Cardiovascular Disease.

Heart DiseaseCoronary heart disease (CHD) is a broad term that describes any disorder that can impact the functioning of the heart muscle itself or the whole cardiovascular system. Conditions that contribute to heart disease include high blood pressure, arteriosclerosis (the build-up of calcium deposits on the artery wall) and atherosclerosis (the build-up of fatty deposits on the artery wall).

The causes of heart disease include: elevated LDL “bad” cholesterol, low HDL “good” cholesterol, obesity, elevated blood pressure, Type 2 Diabetes, cigarette smoking and lack of physical activity. Many of these are underlying conditions found in both Insulin Resistance and Metabolic Syndrome.

Chronic high levels of glucose and insulin are classic symptoms of Insulin Resistance and Metabolic Syndrome. One of the primary risk factors for atherosclerosis, a form of hardening of the arteries, is an elevated level of triglycerides. The biggest risk factor for increasing the production of triglycerides is the rate of your insulin secretion.
Kids and Metabolic Syndrome
"... metabolic syndrome is as serious a condition among children as it is among adults and preventive steps should be taken immediately in children who exhibit this condition to ward off premature heart disease."
Prevention of Heart Disease Should Begin in Childhood, Diabetes Care, American Diabetes Association

Insulin is produced in your pancreas and released into the circulatory system where it is the key to the absorption of glucose by your cells. If your cells resist insulin, then both insulin and glucose build up in your blood. Excess insulin leads to weight gain and high blood pressure – both precursors to Cardiovascular Disease. As insulin comes in contact with the interior wall of the arteries, it damages the tissue, causing the initial injury that produces plaque. Therefore, having Insulin Resistance and Metabolic Syndrome directly cause changes in the blood lipids and overall cardiovascular health that contribute to the formation of heart disease.

Recommendations for reducing heart disease risk are the same as those for reducing Insulin Resistance, namely decreasing insulin, balancing cholesterol and lowering blood pressure. It all involves managing Metabolic Syndrome to minimize current symptoms and an attempt to delay or prevent worsening of the underlying conditions that lead to heart disease. This can be done through careful food choices, including a low cholesterol diet, exercise and weight loss in overweight individuals. But a multi-faceted approach is clearly necessary to address all the symptoms of these conditions.

A complete system is required that includes nutraceuticals (vitamins, herbs and minerals that are disease specific), a realistic exercise program combined with nutritional guidance and a support network that will help you change unhealthy lifestyle choices.

Click here to read about the scientific breakthrough called the Insulite MetaX System, which is designed to help reduce heart disease risk factors such as high cholesterol and hypertension (high blood pressure) by restoring your balance of glucose and insulin levels. Among the system's formulations is InsulX, which includes vanadium, a compound that helps to lower "bad" LDL cholesterol.

You may be interested in some of our Frequently Asked Questions (FAQs) about Metabolic Syndrome and the Insulite MetaX System.

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Metabolic Syndrome and Cardiovascular Disease

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Insulin Resistance Articles
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Teresa Ruth
  Boise, Idaho
"Researchers agree that insulin resistance is central to the metabolic syndrome. When target cells are unresponsive to insulin, the pancreas responds by pouring even more insulin into the bloodstream, leading to high levels of the hormone in the blood, a condition called compensatory hyperinsulinemia. The high level of insulin in the blood forces glucose into cells but also starts the events leading to arterial damage and eventually a heart attack. Under these conditions, a person may not manifest either diabetes or heart disease but could well be on the way to either or both."
A. MAUREEN ROUHI, Chemical and Engineering News. November 22, 2004.Vol. 82, No.47  
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  Stuarts Draft, VA
"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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  Perth, Australia
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"A non-pharmacologic treatment for these patients is needed, since drugs prescribed to lower blood pressure have been shown to actually worsen carbohydrate and lipid metabolism in Syndrome X patients, negating the beneficial effects of those drugs."
Duke University Study, results published in the Archives of Internal Medicine, September 2003.
Article by Dr. Sheri Colberg, Phd, FACSM
"I cannot believe the difference the Insulite System has made in how I feel. My appetite has changed tremendously. I do not crave carbs and sugar and my appetite is somewhat diminished."
  Bakersfield, CA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
"To gain the most benefit from modifying multiple metabolic risk factors, the underlying insulin-resistant state must become a target of therapy."
Bogdanovic, Streten and Langlans, Beata, "Metabolic Syndrome: New Opportunities in Diagnostics and Therapeutics", DMD Publications, 2004.  
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